From our previous website’s article collection. Dates, prices and treatment information reflect the original publication period.
Quick Answer: Applying PRP and mesotherapy to the décolleté area is an effective regenerative treatment combination for area-specific concerns such as rhomboid wrinkles, thin skin texture, pigmentation and laxity. PRP (platelet-rich plasma) stimulates collagen synthesis through PDGF, TGF-β and IGF growth factors, while mesotherapy delivers HA and vitamin cocktails directly into the dermis for immediate hydration and radiance. Typical protocol: 3–4 monthly PRP sessions, followed by 3–4-month maintenance.The Unique Anatomy of the Décolleté and Ageing Concerns
The décolleté area (upper chest, lower neck, the area between the collarbones) has different characteristics from the face, and directly applying facial treatments does not always yield suitable results. Area-specific signs of ageing include:
- Rhomboid wrinkles: Sun damage-related, deep network pattern with small square/rhomboid shapes — a photoageing sign unique to the décolleté, rarely seen on the face
- Skin thinning: Reduction in dermal thickness, loss of subcutaneous fat; the skin takes on a "paper-like" appearance
- Solar lentigo and hyperpigmentation: Pigment accumulation from chronic UV exposure
- Laxity and loss of elasticity: Elastin fibres break down; the skin appears sagging and dull
- Vascular lesions: Telangiectasia and diffuse erythema (Poikiloderma of Civatte)
Due to the multi-component nature of this picture, a single treatment modality is insufficient. Combined protocols using PRP and mesotherapy together have become the gold-standard approach in décolleté rejuvenation.
Mechanism of Action of PRP on the Décolleté
PRP (Platelet Rich Plasma) is a biological product obtained by centrifuging the patient's own blood, with platelet concentration raised to 4–8 times that of normal plasma. When applied to the décolleté, the following growth factors are activated:
| Growth Factor | Abbreviation | Effect |
|---|---|---|
| Platelet-Derived Growth Factor | PDGF | Fibroblast proliferation, angiogenesis (new vessel formation), Type I and III collagen synthesis |
| Transforming Growth Factor Beta | TGF-β | Extracellular matrix synthesis, elastin production, wound repair coordination |
| Insulin-Like Growth Factor | IGF-1 | Keratinocyte proliferation, increase in skin thickness |
| Vascular Endothelial Growth Factor | VEGF | Microcirculation improvement, skin tone correction |
| Epidermal Growth Factor | EGF | Accelerated cell renewal, improved epidermis quality |
During PRP application to the décolleté, micro-depot injections are made into the dermis using fine needles. Subsequently, PRP can optionally be applied topically by rubbing with a dermaroller or dermapen (channel technique) — this enhances superficial infusion.
Mesotherapy Content Options: Special Formulations for the Décolleté
Mesotherapy involves delivering mixtures of active substances into the dermis via numerous small injections. Mesotherapy cocktails targeting the décolleté may contain the following ingredients:
- Hyaluronic acid (low viscosity): Intradermal hydration through its immediate water-binding capacity; aimed at softening décolleté wrinkles with moisture rather than filling them
- Vitamin C (ascorbic acid): Inhibition of melanin synthesis (brightening) + cofactor role in collagen synthesis
- B-group vitamins (B5, B6, B12): Skin renewal, metabolic energy support
- Glutathione: Powerful antioxidant; reduction of oxidative stress and improvement of skin tone
- Peptides (matrixyl, argireline): Support for collagen induction and fine wrinkle treatment
- DMAE (dimethylaminoethanol): Skin-tightening effect, surface tone correction
- Amino acids: Fibroblast support as building blocks of collagen and elastin
At Abel Beauty, personalised cocktails are used for décolleté mesotherapy; instead of standard formulas, ingredient selection is made according to the patient's skin type, concerns and season.
PRP vs Mesotherapy: Comparison Table
| Criterion | PRP | Mesotherapy |
|---|---|---|
| Content | Growth factors derived from the patient's own blood | Synthetic/natural active substances (HA, vitamins, peptides) |
| Allergy risk | None (autologous) | Very low (under 1%) |
| Primary effect | Biological regeneration, collagen renewal | Immediate nourishment, hydration, brightening |
| Onset of effect | 2–4 weeks (collagen maturation) | 1–7 days (rapid visible improvement) |
| Indication (décolleté) | Rhomboid wrinkles, skin thinning, loss of elasticity | Pigmentation, dryness, dull skin, superficial fine lines |
| Number of sessions | 3–4 (monthly), then 3–4-month maintenance | 4–6 (every 2 weeks), then monthly maintenance |
| Longevity | 6–12 months (collagen renewal takes longer) | 3–4 months |
| Ideal patient | Those with prominent wrinkles and loss of elasticity | Those with prominent pigmentation, dryness and skin quality concerns |
Combined Protocol: PRP + Laser Synergy
Laser alone or PRP alone yields average results in the décolleté. However, the combined use of both creates a significant synergistic effect:
Why are laser + PRP used together?
- Laser creates controlled damage at the epidermal and dermal level; this "controlled injury" prepares the environment in which PRP's growth factors will work.
- PRP significantly accelerates the healing rate after laser; erythema (redness) and oedema resolve more quickly.
- The anti-inflammatory effects of PRP reduce the risk of post-inflammatory hyperpigmentation (PIH) from laser — a critical advantage especially in darker-skinned patients.
Application sequence: PRP is applied immediately after the laser session is completed (in the same session). Alternatively, a separate PRP session can be planned 48–72 hours after laser.
Session Schedule and Care Protocol
Initial phase (months 1–3):
- Month 1: PRP + mesotherapy (focused on décolleté pigmentation/hydration)
- Month 2: PRP (alone) or PRP + laser
- Month 3: PRP + mesotherapy (result assessment)
Maintenance phase (from month 4 onwards):
- PRP every 3–4 months
- Mesotherapy every 2–3 months
Post-procedure home care:
- First 24 hours: Keep the application area dry; no make-up
- First week: Panthenol-based moisturiser, gentle cleanser
- Ongoing: SPF 50+ sunscreen (including the décolleté)
- Discontinue retinoid and acid-based products 3 days before the procedure and resume 5–7 days after
Who Benefits Most from PRP and Mesotherapy?
The ideal candidate profile for décolleté PRP and mesotherapy:
- Those aged 35–65 with visible photoageing signs in the décolleté area
- Those not ready for surgical procedures or seeking non-surgical solutions
- Those wishing to accelerate the healing process in addition to laser treatment
- Those wishing to improve overall skin quality and achieve a bright, youthful appearance
Contraindications: Thrombocytopaenia, active infection or inflammation, coagulopathy, immune deficiency, pregnancy, active cancer treatment and use of blood-thinning medications.
Abel Beauty Décolleté Rejuvenation Approach
Please contact us for pricing information.
This article is for informational purposes only. Please consult a qualified physician for treatment decisions.
