From our previous website’s article collection. Dates, prices and treatment information reflect the original publication period.
Quick Answer: What Is Profhilo?
Profhilo is a 100% ultra-pure hyaluronic acid (HA)-based bio-remodeling product that contains no BDDE (butanediol diglycidyl ether) crosslinker. Each 2 mL ampoule contains 64 mg of a high-molecular-weight and low-molecular-weight HA combination, injected into 5 strategic points using the BAP (Bio Aesthetic Points) technique. Unlike conventional fillers, it does not add volume; instead, it stimulates collagen, elastin and HA synthesis to provide deep hydration and biological remodeling (bio-remodeling). Standard protocol: 2 sessions spaced 4 weeks apart. Clinical studies report a 12–20% increase in skin elasticity and a 20–30% increase in hydration levels. The effect lasts 6–12 months.
What Is Profhilo? The Concept of Bio-Remodeling
For many years in aesthetic medicine, hyaluronic acid fillers have served as the primary tool for creating "volume" and "contour". Profhilo is a formulation that fundamentally transforms this paradigm: its purpose is not to fill, but to activate the skin's own renewal capacity. The concept of bio-remodeling was born precisely at this point — not to "fill" the tissue from the outside, but to "awaken" it from within.
Of Italian origin, Profhilo is developed by IBSA Farmaceutici and is the only ultra-pure HA formulation that contains no synthetic crosslinker such as BDDE (butanediol diglycidyl ether). Because it is free of BDDE, the product spreads rapidly within tissue, stimulating keratinocytes, fibroblasts and adipocyte stem cells to initiate the synthesis of type I, III and IV collagen as well as elastin.
Profhilo's Chemical Composition and Technology
| Component | Amount / Property | Function |
|---|---|---|
| High-Molecular-Weight HA (H-HA) | ~1,100–1,400 kDa, 32 mg/2 mL | Surface hydration, tissue filling, anti-inflammatory |
| Low-Molecular-Weight HA (L-HA) | ~80–100 kDa, 32 mg/2 mL | Deep penetration, cell receptor activation |
| Crosslinker (BDDE) | ABSENT | High biocompatibility, rapid tissue spread |
| Mannitol | Antioxidant stabiliser | Protects HA from free radicals, extends longevity |
| Total HA concentration | 32 mg/mL (ultra-high) | Twice the concentration of standard HA fillers |
The BAP Technique: 5-Point Injection Protocol
BAP (Bio Aesthetic Points) is a 5-point injection protocol developed by Italian aesthetic surgeon Maurizio Cavallini and specifically standardised for Profhilo. These five anatomical points have been determined through surgical anatomy studies to ensure optimal product distribution across every region of the face:
- Point 1: Below the zygomatic bone — mid-axial point of the cheek
- Point 2: Anterior border of the masseter muscle — lower cheek region
- Point 3: Midpoint of the mandibular line — chin surface line
- Point 4: Level of the tragus — pre-auricular region
- Point 5: Inferior border of the mandibular angle
A depot of 0.2 mL product is placed at each point, delivering a total of 1 mL per hemi-face. This ensures homogeneous distribution across the entire skin layer of the face. The technique can be adapted to anatomical variations; experienced practitioners can apply modified BAP protocols to areas such as the neck, décolleté, dorsum of the hand and inner arms.
Profhilo vs Conventional Hyaluronic Acid Filler: A Comprehensive Comparison
| Feature | Profhilo | Conventional HA Filler |
|---|---|---|
| Treatment goal | Bio-remodeling, tissue renewal | Volume, contour, line filling |
| BDDE crosslinking | ABSENT | PRESENT (for stabilisation) |
| HA concentration | 32 mg/mL (ultra-high) | 15–25 mg/mL |
| Tissue spread | Wide, homogeneous (liquid, not gel) | Localised (remains in gel form) |
| Injection technique | BAP — 5 points, 0.2 mL/point | Linear, fan, retrograde, bolus |
| Onset of effect | 2–4 weeks (gradual biological) | Immediate (mechanical volume) |
| Duration of effect | 6–12 months | 6–18 months (depends on product and area) |
| Natural appearance | Very high — "like your own skin" | Depends on physician skill and product |
| Collagen stimulation | Yes — type I, III, IV collagen + elastin | Limited (primarily filling mechanism) |
| Age group | 30–65+ (preventive + restorative) | 35+ (mostly after noticeable loss) |
Profhilo vs Juvederm Volite: Differences and Similarities
Juvederm Volite is also an HA product targeting skin quality improvement; however, the low level of BDDE it contains distinguishes it technologically from Profhilo. Volite spreads less within tissue and targets hydration and superficial fine lines. Profhilo, by contrast, has no BDDE and can spread over a wider area, and with a hyaluronic acid concentration approximately three times higher, it offers a deeper remodeling effect and a longer tissue distribution capacity. In terms of injection point count, Profhilo covers an entire hemi-face with its 5 BAP points, while Volite may require a greater number of injection sites.
Profhilo Application Protocol: Step by Step
- Consultation and skin analysis: Skin type, stage of ageing, existing concerns and expectations are assessed; clinical photography is performed.
- Cleansing and disinfection: The treatment area is cleansed with chlorhexidine or alcohol.
- Topical anaesthesia (optional): EMLA cream applied for 20–30 minutes based on patient preference or sensitivity; most patients report this is not necessary.
- BAP injection: A total of 10 injections at 5 BAP points on each hemi-face; procedure duration approximately 15–20 minutes.
- Post-procedure cold application: Ice pack applied for 5–10 minutes for mild oedema or redness.
- Aftercare instructions: No makeup for 24 hours, no facial massage or sauna for 48 hours, avoid intense exercise for 1 week.
Expected Results: Clinical Timeline
Profhilo's effect profile is gradual and biological; unlike conventional fillers, no immediate volume increase is observed. The clinical timeline is as follows:
- Weeks 1–2: Deep hydration sensation, increased skin softness, mild plumping
- Weeks 2–4: Improvement in skin texture, reduced pore visibility, softening of fine lines
- After 2nd session (weeks 6–8): Noticeable tightening, evening of skin tone, increased luminosity and vitality
- Months 3–6: Late gains from collagen remodeling continue; definition of oval facial contours becomes more pronounced
Studies by Savoia et al. (2016, Journal of Cosmetic and Laser Therapy) and Urdiales-Gálvez et al. (2018) reported a 12–20% increase in skin elasticity, a 20–30% increase in hydration levels and significant improvement in dermal thickness following Profhilo treatment. Patient satisfaction survey results show 88% "marked improvement" at 4 weeks post-procedure.
How Many Sessions Are Needed? Maintenance Protocol
| Profile | Initial Protocol | Maintenance |
|---|---|---|
| Ages 30–40 (preventive) | 2 sessions, 4 weeks apart | 1–2 sessions per year |
| Ages 40–55 (restorative) | 2–3 sessions, 4 weeks apart | 2 sessions per year |
| Ages 55+ (intensive) | 3 sessions, 3–4 weeks apart | 2–3 sessions per year |
| Neck / décolleté | 2 sessions, 4 weeks apart | 2 sessions per year |
Treatment Areas: Beyond the Face
Profhilo is not limited to the face. Other areas where we successfully apply it at Abel Beauty include:
- Neck and décolleté: High satisfaction outcomes are achieved in these areas where crepey skin, fine lines and uneven tone are most apparent.
- Dorsum of the hand: Ideal for addressing skin thinning, visible veins and moisture loss.
- Inner arms and around the knees: Effective for thin, lax skin appearance and crepey texture.
- Periorbital area: Modified, low-dose periorbital protocol (this area requires an experienced practitioner).
- Abdomen following weight loss or pregnancy: Can be used as a skin quality restoration protocol.
Who Is It Suitable For? Contraindications
Profhilo is suitable for any individual over 30 who wishes to preserve or improve skin quality, who is seeking a more natural form of rejuvenation rather than volume filler, and who wishes to manage ageing prophylactically. Contraindications include:
- Pregnancy and breastfeeding
- Active skin infection or acute herpes simplex activation
- Known allergy to HA or streptococcal components
- Autoimmune diseases (relative contraindication; individual assessment required)
- Use of anticoagulant medications (assessment before the procedure and temporary discontinuation if necessary)
- Predisposition to keloid formation (particularly caution in the neck area)
Side Effects and Safety Profile
Because it contains no BDDE, Profhilo's safety profile is markedly advantageous compared to conventional crosslinked fillers. Transient and expected side effects include: small swellings at injection points (1–3 days), mild bruising (3–7 days), redness (24–48 hours). Serious complications such as granuloma formation, vascular occlusion and delayed-type hypersensitivity are extremely rare and are largely related to practitioner experience and the product's BDDE-free formulation.
Combined Treatment Strategies with Profhilo
While Profhilo is effective as monotherapy, maximum results are achieved when combined with other procedures. Frequently used combination protocols at Abel Beauty:
- Profhilo + Botox: Expression lines are targeted with Botox while skin quality is addressed with Profhilo. The most frequently chosen combination.
- Profhilo + PRP: Powerful tissue renewal effect through the synergy of growth factors and HA.
- Profhilo + Mesotherapy: A strong complement for superficial skin quality and radiance.
- Profhilo + HA Filler: Filler provides contour and volume while Profhilo enhances overall skin quality; can be performed in the same session.
Profhilo at Abel Beauty
Frequently Asked Questions
Is Profhilo painful? Most patients describe the injections as mild pressure or a needle sensation. Comfort can be enhanced with topical anaesthetic cream.
Can Profhilo and filler be performed at the same time? Yes, they can be combined in the same session. Filler provides contour and volume while Profhilo improves overall skin quality; the two effects are complementary.
Is the effect of Profhilo permanent? No; HA is naturally metabolised by the body. A maintenance session is recommended after an average effect duration of 6–12 months. With regular maintenance, cumulative collagen gains continue to accumulate.
Is Profhilo only for mature skin? No. Starting early as "preventive bio-remodeling" in one's thirties helps prevent more dramatic signs of ageing from developing in later years. For those aged 30–40, a preventive session frequency of once or twice per year is sufficient.
This article is for informational purposes only. Please consult a qualified physician for treatment decisions.
